Preparation, Characterization and Optimization of Poloxamer Solid Dispersions of a Poorly Water Soluble Drug Aprepitant
نویسندگان
چکیده
منابع مشابه
Preparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers
Objective(s):Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). Materials and Methods: Solid dispersions of CLX:PVP or CLX:PLX were prepared at different r...
متن کاملSolubility Enhancement of a Poorly Water Soluble Drug by Forming Solid Dispersions using Mechanochemical Activation
Mechanochemical activation is a practical cogrinding operation used to obtain a solid dispersion of a poorly water soluble drug through changes in the solid state molecular aggregation of drug-carrier mixtures and the formation of noncovalent interactions (hydrogen bonds) between two crystalline solids such as a soluble carrier, lactose, and a poorly soluble drug, indomethacin, in order to impr...
متن کاملpreparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and pvp-k30 as carriers
objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...
متن کاملPreparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers
OBJECTIVES Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND METHODS Solid dispersions of CLX:PVP or CLX:PLX were prepared at different ra...
متن کاملCharacterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus®.
Solid dispersions are a useful approach to improve the dissolution rate and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The aim of this study was to improve the physicochemical properties and bioavailability of a poorly water-soluble aprepitant by preparation of solid dispersions. The solid dispersions were characterized by dissolution, FTIR, XRPD, DSC, SEM...
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ژورنال
عنوان ژورنال: British Journal of Pharmaceutical Research
سال: 2014
ISSN: 2231-2919
DOI: 10.9734/bjpr/2014/10561